This is our recommendation.
Karlovy Lázně – This night club is one of the largest in Central Europe, with five floors of music and dance. Each floor has a different theme, from classic rock to EDM to hip hop. The club has a lively, energetic atmosphere and attracts a mix of locals and tourists. Address: Smetanovo nábřeží 198/1, 110 00 Prague 1
Roxy – This popular nightclub has been a fixture of Prague's nightlife scene since 1992. The club hosts a mix of live music and DJ events in genres from indie rock to techno to hip hop. The interior has a raw, industrial feel, with exposed brick walls and metal beams. Address: Dlouhá 33, 110 00 Prague 1
Cross Club – This unique nightclub is popular with Prague's alternative crowd. The interior is decorated with steampunk-inspired sculptures and installations, and the music ranges from drum and bass to dubstep to world music. The club also regularly hosts art exhibitions and cultural events. Address: Plynární 1096/23, 170 00 Prague 7
Duplex – This stylish rooftop nightclub around the Seven Days Boutique Hotel offers a stunning view of the Prague skyline and the Vltava River. The club has a sophisticated, luxurious atmosphere and a dress code is required on weekends. The music ranges from house to R&B to Latin and the club often hosts international DJs. Address: Václavské náměstí 21, 110 00 Prague 1
M1 Lounge – This luxury nightclub and cocktail bar has a glamorous, cosmopolitan atmosphere. The interior features plush leather sofas and crystal chandeliers, and the music ranges from commercial pop to electronic dance. The club also offers a variety of creative cocktails and premium spirits. Address: Masná 705/1, 110 00 Prague 1